Antimicrobial resistance is on the rise in the EU – EFSA

Antimicrobial resistance is on the rise in the EU, with bacteria in humans, food and animals continuing to show resistance to the most widely used antimicrobials, the latest EFSA report has found.

Scientists are warning that resistance to ciprofloxacin, an antimicrobial that is critically important for the treatment of human infections, is very high in Campylobacter.

This in turn reduces the options for effective treatment of severe foodborne infections.

It also found that multi-drug resistant Salmonella bacteria continue to spread across Europe.

The report was published ahead of a vote on draft legislation to tackle growing antimicrobial resistance in animals in the EU’s Environment and Public Health Committee this week.

The committee is to vote on stricter rules on the use of existing antibiotics and by stimulating the development of new veterinary medicines across the EU.

The findings of this latest annual Europe-wide report by the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC) underline that antimicrobial resistance poses a serious risk to human and animal health.

This risk was identified by the Commission as a major priority in its political agenda on food safety.

EU Commissioner for Health and Food Safety, Vytenis Andriukaitis, has said that every year in the EU, infections caused by antimicrobial resistance lead to about 25,000 deaths – but the threat is not confined to Europe.

He said that this is a global problem that requires a global solution.

The EU has long been at the forefront in the fight against antimicrobial resistance and is a leader in the field.

“Our agencies EFSA and ECDC, by combining their expertise in human and animal health, are putting together many of the pieces in this complex puzzle and providing policy makers the world over with valuable scientific advice.”

The report also found evidence of resistance to the antimicrobial colistin in Salmonella and E. coli among poultry in the EU.

Mike Catchpole, Chief Scientist for ECDC, said that this is worrying because it means that this last-resort drug may soon no longer be effective for treating severe human infections with Salmonella.

In addition to the high levels of resistance shown throughout Europe, the report found that there are significant regional differences.

The highest levels of antimicrobial resistance (AMR) are observed in eastern and southern Europe.

Marta Hugas, Head of EFSA’s Biological Hazards and Contaminants unit, said that in northern Europe, there is lower resistance in bacteria from poultry, particularly in countries with low use of antimicrobials in animals.

Key Findings

Campylobacter – Campylobacteriosis, the disease caused by Campylobacter, is the most commonly reported foodborne disease in the EU.

Resistance to widely used antimicrobials, such as ciprofloxacin, was commonly detected in bacteria from humans and poultry.

High to extremely high resistance to ciprofloxacin was observed in broilers (69.8%), as well as in bacteria from humans (60.2%).

High to extremely high resistance to nalidixic acid and to tetracyclines was reported in broilers.

Salmonella – Salmonellosis is the second most commonly reported foodborne disease.

Resistance to widely used antimicrobials was commonly detected in Salmonella from humans (tetracyclines 30%, sulphonamides 28.2%, ampicillin 28.2%) and poultry.

The prevalence of multi-drug resistance was high in bacteria in humans (26%), and especially high in broiler and turkey meat (24.8% and 30.5%, respectively).

Some types of Salmonella bacteria, namely Salmonella Kentucky and Salmonella Infantis, are of particular concern as they showed high level of resistance to ciprofloxacin and high multi-drug resistance.